Find 4 Star Hotels in Santa Clara
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Santa Clara 4 Star Hotels
Tonight
Tomorrow
This weekend
Next weekend
Compare Santa Clara 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Hotel Riu Plaza Panama
Hotel Riu Plaza Panama
9.0 out of 10, Wonderful, (3793)
The price is SAR 446
SAR 491 total
includes taxes & fees
1 Apr - 2 Apr

Dreams Playa Bonita Panama - All Inclusive
Dreams Playa Bonita Panama - All Inclusive
7.4 out of 10, Good, (1004)
The price is SAR 1,050
SAR 1,050 total
includes taxes & fees
6 Apr - 7 Apr

The Westin Playa Bonita Panama
The Westin Playa Bonita Panama
8.0 out of 10, Very Good, (1008)
The price is SAR 797
SAR 876 total
includes taxes & fees
5 Apr - 6 Apr

Marriott Panama Hotel
Marriott Panama Hotel
9.0 out of 10, Wonderful, (1008)
The price is SAR 504
SAR 554 total
includes taxes & fees
13 Apr - 14 Apr

JW Marriott Panama
JW Marriott Panama
8.8 out of 10, Excellent, (1005)
The price is SAR 1,159
SAR 1,275 total
includes taxes & fees
11 Apr - 12 Apr

Decapolis Hotel Panama City
Decapolis Hotel Panama City
8.4 out of 10, Very Good, (1112)
The price is SAR 351
SAR 387 total
includes taxes & fees
28 Mar - 29 Mar

W Panama
W Panama
8.8 out of 10, Excellent, (1002)
The price is SAR 773
SAR 850 total
includes taxes & fees
11 Apr - 12 Apr

Ramada Plaza By Wyndham Panama Punta Pacífica
Ramada Plaza By Wyndham Panama Punta Pacífica
9.6 out of 10, Exceptional, (1005)
The price is SAR 375
SAR 413 total
includes taxes & fees
1 Apr - 2 Apr
Save an average of 15% on thousands of hotels when you're signed in
Learn more about Santa Clara
Santa Clara awaits: its natural setting, monuments, history, and more!

Recent reviews of Santa Clara hotels
Recent reviews of Santa Clara hotels

Novotel Panama City
5/5 Excellent
"I liked the location, its nearest to many restaurants, shopping, and pampering facilities.
The staff was really outstanding, helpful, and sermed to genuinely care about my experience in their hotel and in their country."
A verified traveler stayed at Novotel Panama City
Posted 2 days ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Santa Clara Hotels by Star Rating
Stay near popular Santa Clara attractions
- Hotels near Culebra Cut
- Hotels near Albrook Shopping Mall
- Hotels near Multiplaza Pacific Mall
- Hotels near Amador Causeway
- Hotels near Cinta Costera
- Hotels near Avenida Balboa
- Hotels near Colon Free Zone
- Hotels near Via Espana
- Hotels near El Dorado Mall
- Hotels near Fuerte Amador Resort & Marina
- Hotels near Veracruz Beach
- Hotels near Miraflores Locks
- Hotels near Panama Viejo
- Hotels near Metromall Panama
- Hotels near Gamboa Rainforest Resort
- Hotels near Iglesia del Carmen
- Hotels near Los Pueblos Commercial Center
- Hotels near ATLAPA Conventions Center
- Hotels near Calle 50
- Hotels near Uruguay Street
More Accommodation Types in Santa Clara
- Apartments in Santa Clara
- Condo Rentals in Santa Clara
- Vacation Homes in Santa Clara
- Aparthotels in Santa Clara
- Hostels in Santa Clara
- B&B in Santa Clara
- Guest Houses in Santa Clara
- Lodges in Santa Clara
- Villas in Santa Clara
- Farmstay in Santa Clara
- Cabin Rentals in Santa Clara
- Cottages in Santa Clara
- Resorts in Santa Clara
- Houseboats in Santa Clara
- Pensions in Santa Clara
Explore more hotels
- Ramada Plaza By Wyndham Panama Punta Pacífica
- The Executive Hotel
- Megapolis Hotel Panamá
- Sheraton Grand Panama
- Novotel Panama City
- Waldorf Astoria Panama
- Hotel Ojos del Rio
- Plaza Paitilla Inn Hotel
- TRYP by Wyndham Panamá Centro
- Las Americas Golden Tower Panama
- Sofitel Legend Casco Viejo, Panama City
- Hospedium Princess Hotel Panama
- Bristol Panama, a Registry Collection Hotel
- Holiday Inn Panama Distrito Financiero by IHG
- Hilton Panama
- Central Hotel Panama Casco Viejo
- Studio Coliving
- Waymore Hotel Spa & Casino
- MARINN PLACE Financial District
- The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City