Upstate South Carolina Vacations

Book a Hotel + Flight together to unlock savings

  • Plan, book, travel with confidence

    • payments icon
    Better together
    Save up to SAR 390 when you book a flight and hotel together*
    lob hotels icon
    Find the right fit
    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon
    Rest easy
    Plan, book, and manage your trip all in one place

Where to stay in Upstate South Carolina

Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
Greenville featuring autumn leaves, a garden and a bridge

Greenville Downtown

2 out of top 10 points of interest in this area
5/5(654 area reviews)

The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.

Find hotels in Greenville Downtown

Find the Best Upstate South Carolina Vacation Packages

Upstate South Carolina Hotel Deals

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
3.5 out of 5
851 Congaree Rd, Greenville, SC
Fully refundable
The price is SAR 356 per night from Apr 20 to Apr 21
SAR 356
SAR 392 total
includes taxes & fees
20 Apr - 21 Apr
8.4/10 Very Good! (1,001 reviews)
"Friendly staff and nice room"

Reviewed on 6 April 2025

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Hilton Greenville
Hilton Greenville
3.5 out of 5
45 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is SAR 475 per night from May 1 to May 2
SAR 475
SAR 538 total
includes taxes & fees
1 May - 2 May
8/10 Very Good! (1,001 reviews)
"The room was clean, the beds are too firm for me and the water pressure was very low. Other then that it was fine."

Reviewed on 15 April 2025

Hilton Greenville
Hyatt Regency Greenville
Hyatt Regency Greenville
3.5 out of 5
220 N Main St, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is SAR 507 per night from May 4 to May 5
SAR 507
SAR 574 total
includes taxes & fees
4 May - 5 May
8.6/10 Excellent! (1,008 reviews)
"My wife and I really enjoyed our stay at the Hyatt Regency in Greenville. The location is excellent and within walking distance to everything downtown. The staff are also very friendly. The hotel also has a lot of space and seating in the event that you need to work. We highly recommend staying ..."

Reviewed on 15 April 2025

Hyatt Regency Greenville
See all 2,598 properties in Upstate South Carolina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Upstate South Carolina

Clemson University

Clemson University

5/5(410 reviews)

Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.

Clemson University
Falls Park on the Reedy

Falls Park on the Reedy

4.5/5(583 reviews)

Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.

Falls Park on the Reedy
Lake Keowee is a man–made reservoir in the United States in the state of South Carolina. It was created to serve the needs of a power utility as well as public recreational purposes. One of my favorite places to go in the summer. The water really is that color.

Lake Keowee

4.5/5(101 reviews)

Commune with nature and explore the great outdoors at Lake Keowee during your travels in Salem. While you're in the area, wander around the college campus.

Lake Keowee