Southeast Missouri Vacations
Book a Hotel + Flight together to unlock savings
- Plan, book, travel with confidence
Better together
Save up to SAR 390 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Find the Best Southeast Missouri Vacation Packages
Southeast Missouri Hotel Deals
The Riverview
777 Main St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is SAR 317 per night from Mar 27 to Mar 28
SAR 317
SAR 358 total
includes taxes & fees
27 Mar - 28 Mar
9.2/10 Wonderful! (174 reviews)
"It is great"
Reviewed on 9 March 2025
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is SAR 354 per night from Mar 30 to Mar 31
SAR 354
SAR 400 total
includes taxes & fees
30 Mar - 31 Mar
9.4/10 Exceptional! (1,012 reviews)
Great stay
"Great stay. Love the atmosphere and food. Our stay was for basketball tournament. Enjoyed every bit of the stay."
Reviewed on 9 March 2025
Motel 6 Poplar Bluff, MO
4101 Highway 67 N, Poplar Bluff, MO
Fully refundableReserve now, pay when you stay
The price is SAR 252 per night from Mar 15 to Mar 16
SAR 252
SAR 266 total
includes taxes & fees
15 Mar - 16 Mar
7.8/10 Good! (1,001 reviews)
"Good service"
Reviewed on 11 March 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Southeast Missouri
Elephant Rocks State Park
5/5(13 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Lake Wappapello
4/5(18 reviews)
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
Echo Bluff State Park
4.5/5(8 reviews)
You can take time to visit Echo Bluff State Park during your travels to Salem. While you're in the area, stroll along the riverfront.