Southeast Minnesota Vacations
Book a Hotel + Flight together to unlock savings
- Plan, book, travel with confidence
Better together
Save up to SAR 390 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Where to stay in Southeast Minnesota
Find the best Southeast Minnesota areas and neighborhoods for the activities you enjoy most. Learn more about Southeast Minnesota
Downtown Rochester
2 out of top 10 points of interest in this area
If you're spending some time in Downtown Rochester, Mayo Civic Center and Rochester Civic Theater are top sights worth seeing.
Find the Best Southeast Minnesota Vacation Packages
Southeast Minnesota Hotel Deals
Kahler Grand Hotel
20 2nd Ave Sw, Rochester, MN
Fully refundableReserve now, pay when you stay
The price is SAR 554 per night from Apr 25 to Apr 26
SAR 554
SAR 638 total
includes taxes & fees
25 Apr - 26 Apr
8.2/10 Very Good! (1,347 reviews)
"Close to Mayo clinic with underground access to clinic. Helpful staff. Pretty easy to find Broken roller on chair in room Bathtub faucet shower lever stuck Parking in parking garage high price, but easily accessed from hotel No street level parking. Bad rib steaks!"
Reviewed on 20 April 2025
AmericInn by Wyndham Rochester Near Mayo Clinic
1625 Broadway Ave S, Rochester, MN
Fully refundableReserve now, pay when you stay
The price is SAR 287 per night from Apr 29 to Apr 30
SAR 287
SAR 330 total
includes taxes & fees
29 Apr - 30 Apr
8/10 Very Good! (820 reviews)
"We had a one night stay. The room was clean and the breakfast was nice."
Reviewed on 23 April 2025
Med City Inn & Suites - Mayo Clinic Area
435 16th Ave Nw, Rochester, MN
Fully refundableReserve now, pay when you stay
The price is SAR 300 per night from Apr 25 to Apr 26
SAR 300
SAR 346 total
includes taxes & fees
25 Apr - 26 Apr
7.8/10 Good! (1,004 reviews)
"Noisy, windows need replacing."
Reviewed on 15 April 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Southeast Minnesota
Winona State University
4.5/5(94 reviews)
Enjoy the collegiate vibe when you visit Winona State University, during your trip to Winona. Stroll along the riverfront or experience the area's museums.
Forestville Mystery Cave State Park
4.5/5(10 reviews)
Commune with nature and explore the great outdoors at Forestville Mystery Cave State Park during your travels in Preston. Wander the parks or discover the area's countryside.
Niagara Cave
4.5/5(10 reviews)
Commune with nature and explore the great outdoors at Niagara Cave during your travels in Harmony. Amble within the natural setting or visit the churches in this family-friendly area.