
Santa Ana Vacations
Book a Hotel + Flight together to unlock savings
- Plan, book, travel with confidence
Better together
Save up to SAR 390 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Where to stay in Santa Ana
Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana

Casco Viejo
4.5/5(178 area reviews)
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Metropolitan Cathedral of Panama or Interoceanic Canal Museum while you're exploring the area.
Santa Ana Hotel Deals

Casco View Apartments
C. 16 Oeste, Panama City, Provincia de Panamá
9.6/10 Exceptional! (14 reviews)
"It was a beautiful view of the ocean and the city from where I was. My friend unfortunately did not have as good of a view as me but I guess that's the luck of the draw."
Reviewed on 24 February 2025

Hotel Riu Plaza Panama
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is SAR 469 per night from Apr 1 to Apr 2
SAR 469
SAR 516 total
includes taxes & fees
1 Apr - 2 Apr
9/10 Wonderful! (3,713 reviews)
"This hotel is well situated and offers super service. The staff is very friendly and helpful. I always stay here when I am in Panama and treatment is always the best."
Reviewed on 4 March 2025

Dreams Playa Bonita Panama - All Inclusive
KM 7, Road to Veracruz, Veracruz, Panama
The price is SAR 1,433 per night from Mar 19 to Mar 20
SAR 1,433
SAR 1,433 total
includes taxes & fees
19 Mar - 20 Mar
7.2/10 Good! (1,004 reviews)
"Angi at the buffet was great. Typical all inclusive. Not really a kids resort but they had a good time. They didnt have an onsite photographer which would have been nice. The food was good. We only ate at 3 out of the 4 places since one didnt allow kids. We had preferred but couldnt use that pool ..."
Reviewed on 3 March 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Santa Ana

Multiplaza Pacific Mall
4.5/5(634 reviews)
During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Avenida Balboa
4/5(554 reviews)
You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.

Cinta Costera
4.5/5(456 reviews)
Explore the great outdoors at Cinta Costera, a lovely green space in Panama City. While you're in the area, stroll along the seaside.