Find Luxury Hotels in Main Street Hyannis, MA

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Pick from 4 Main Street Hyannis Luxury Hotels and compare room rates, reviews, and availability. Most hotels are fully refundable.

Hyannis Plaza Hotel
Outdoor pool
Hyannis Plaza Hotel
2.5 star property
6.8 out of 10, (672)
"I paid online for the weekend and then an additional amount that I didn’t know about when checking in and I was told that it would be back in my account Monday morning and have not received it yet. "
The price is SAR 286
SAR 359 total
includes taxes & fees
26 Nov - 27 Nov
Hyannis Plaza Hotel
Americas Best Value Inn & Suites Hyannis Cape Cod
Pool
Americas Best Value Inn & Suites Hyannis Cape Cod
2.0 star property
7.6 out of 10, Good, (1002)
"Cute beachy stay in the heart of Hyannis! Super walkable and near the harbor!"
Americas Best Value Inn & Suites Hyannis Cape Cod
Cape Cod Inn
Exterior
Cape Cod Inn
2.0 star property
8.8 out of 10, Excellent, (422)
"The Cape Cod Inn is a decent motel. The rooms are clean and spacious and quiet. We found it very convenient to park outside our door. It’s a very short walk to restaurants and shops and a ten minute walk to the ferry to either Nantucket or Martha’s Vineyard. Good value for the money, would definitely stay again. "
Cape Cod Inn
Comfort Inn Hyannis - Cape Cod
Exterior
Comfort Inn Hyannis - Cape Cod
2.5 star property
7.6 out of 10, Good, (1003)
"Have stayed here many times. It is always quiet and comfortable."
The price is SAR 343
SAR 392 total
includes taxes & fees
29 Nov - 30 Nov
Comfort Inn Hyannis - Cape Cod
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Are you looking for a luxury hotel for your stay in Main Street Hyannis?
During your visit, you might want to enjoy the beaches and shopping which Main Street Hyannis is known for.
What's the best high-end place to stay in Main Street Hyannis?
Hyannis Plaza Hotel is a luxury hotel with a seasonal outdoor pool and a bar, and it’s a popular choice for Expedia travelers looking for an elegant place to stay.
How many luxury hotels can I expect to find in Main Street Hyannis?
Lie in the lap of luxury during your getaway to Main Street Hyannis in one of Expedia’s 6 luxury hotels.
When can I expect good weather in Main Street Hyannis?
Planning for the weather is an important factor for making your trip to Main Street Hyannis a success, especially when you’re splurging. The hottest months are usually August and July with an average temp of 67°F, while the coldest months are February and January with an average of 37°F. Average annual precipitation for Main Street Hyannis is 52 inches.
What's there to see and do in Main Street Hyannis?
Experience Main Street Hyannis with a stop at John F. Kennedy Hyannis Museum, Cape Cod Baseball Hall of Fame, and Wackenhammer’s Clockwork Arcade. If you have extra time while you’re in the area, you might want to stop by Cape Cod Maritime Museum and Hyannis Harbor.