Visit South Main
Popular places to visit
George R. Brown Convention Center
During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the great live music and acclaimed art scene in this vibrant area.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the entertainment choices and acclaimed art scene in this vibrant area.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the lively festivals and acclaimed theater scene in this vibrant area.
Rice University
Enjoy the collegiate vibe around Rice University, a top university in Houston. Experience the area's lively festivals and acclaimed theater scene.
Space Center Houston
Study the exhibits at Space Center Houston, a favorite museum in Houston. Amble around the area's lakeside or attend a sporting event.
South Main Hotel Deals
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Reviewed on 31 March 2025
Other neighborhoods around South Main
Astrodome
If you're spending time in Astrodome, check out sights like NRG Stadium or NRG Arena and hop on the metro to see more the city at Stadium Park/Astrodome Station or Smith Lands Station.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Houston Museum District
Known for its ample dining options and fascinating museums, there's plenty to explore in Houston Museum District. You can visit top attractions like Children's Museum of Houston and Houston Natural Science Museum, and jump on the metro at M. D. Anderson Station or Museum District Station to see more of the city.
South Central Houston
If you're spending time in South Central Houston, check out sights like Children's Museum of Houston or Houston Natural Science Museum and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Westheimer Rd while you're exploring the area.
Greater Third Ward
While you're in Greater Third Ward, take in top sights like Fertitta Center or 2209 Dowling Street, and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
- MD Anderson Cancer Center
- NRG Stadium
- George R. Brown Convention Center
- Toyota Center
- Daikin Park
- Rice University
- University of Houston
- Houston Zoo
- Westheimer Rd
- NRG Park
- Memorial City Mall
- Downtown Aquarium
- CityCentre
- Smart Financial Centre at Sugar Land
- Sugar Land Town Square
- NRG Center
- Lakewood Church
- Pearland Town Center
- House of Blues Houston
- Sam Houston Race Park
- Children's Museum of Houston
- Discovery Green
- Texas Southern University
- Houston Natural Science Museum
- Baybrook Mall
- Hobby Center for the Performing Arts
- Houston Methodist Hospital
- Hermann Park
- Greenway Plaza
- Houston Museum of Fine Arts
- Texas Children's Hospital
- Memorial Park