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Compare hotels close to Edisto Island Serpentarium with room rates, reviews, and availability. Most hotels are fully refundable.
Hotels near Other Edisto Island Attractions
Hotels near Other Edisto Island Attractions

Botany Bay Plantation
4.5/5(8 reviews)
Explore the great outdoors at Botany Bay Plantation, a lovely green space in Edisto Island. Stroll along the beaches in this relaxing area, or seek out the fishing spots.
Recent reviews of Edisto Island Serpentarium hotels
Recent reviews of Edisto Island Serpentarium hotels

4 Bedroom 2 Bath Ocean Front Vacation Rental on Edisto Beach
5/5 Excellent
The patrick
"This was a wonderful clean place. Beach front and the back deck was amazing. I loved this place. "
A verified traveler stayed at 4 Bedroom 2 Bath Ocean Front Vacation Rental on Edisto Beach
Posted 6 days ago
Explore a world of travel with Expedia
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Hotels near popular Edisto Island Attractions
- Hotels near Edisto Beach State Park
- Hotels near Kiawah Beachwalker Park
- Hotels near Freshfields Village
- Hotels near Night Heron Park
- Hotels near Turtle Point Golf Course
- Hotels near Botany Bay Plantation
- Hotels near The Ocean Course
- Hotels near Bohicket Marina
- Hotels near Cougar Point Golf Course
- Hotels near Botany Bay Plantation Heritage Preserve and Wildlife Management Area
- Hotels near ACE Basin National Wildlife Refuge
- Hotels near The Resort Shop
- Hotels near Oak Point Golf Course
- Hotels near Plantation Course at Edisto
- Hotels near Osprey Point
- Hotels near Edisto Island Museum
- Hotels near Irvin House Vineyards
- Hotels near With These Hands Gallery
Other Hotels near Edisto Island Serpentarium, Edisto Island
- Charleston Hotels
- Folly Beach Hotels
- Kiawah Island Hotels
- Beaufort Hotels
- Edisto Island Hotels
- Edisto Beach Hotels
- Seabrook Island Hotels
- Johns Island Hotels
- Saint Helena Island Hotels
- Coastal South Carolina Hotels
- Harbor Island Hotels
- Hunting Island Hotels
- Yemassee Hotels
- Wadmalaw Island Hotels
- Southeastern United States Hotels
- Oceanmarsh Subdivision Hotels
- The Carolinas Hotels
- Hollywood Hotels
- Seabrook Hotels
- Jacksonboro Hotels
Explore more hotels
- Just Renovated! Welcome to I-Land Style 4BR, 2BTH OCEANFRONT on Edisto Beach
- Dog-Friendly Home Right On Beach w/ Private Washer/Dryer & Free WiFi
- 3 bedroom elevated chic home tucked among the trees~ The Paper House
- Stowe Away - Pet Friendly
- 4 Bedroom 2 Bath Ocean Front Vacation Rental on Edisto Beach
- Relaxing water view home near the beach with furnished deck, spacious interior
- Renovated corner condo with tropical balcony, pool, AC & W/D - walk to beach
- Ocean Front Home with Breath Taking Views!
- Top-floor 3rd-row condo with balcony, AC, outdoor pool & beach access
- Oceanfront Showplace - Island Manor
- 2nd row Ocean Views 4br 3ba Sleeps 12, '25 Pool Amenity Card, linens included
- Dog-Friendly House Across the Street From Beach w/Private Pool, WiFi, AC, Patio