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Check prices for these dates

Compare 86 Apartments in Defiance with updated reviews, rates, and availability.

The Lofts of North Main Street

9.6 out of 10, Exceptional, (124)
"Spent 3 days in St Charles. This was our second visit to St. Charles, just a different season. An ice sculpture event was taking place on our first day. We loved the location. So close to everything we wanted to do. Able to walk everywhere. The condo was perfect for us. The 2 bathrooms, 2 bedrooms, gave us the privacy we needed. The open living room, kitchen area was very nice. The hosts were great to work with. Communication was quick and helpful. I would definitely rent this unit again. "
The price is SAR 484
SAR 989 total
includes taxes & fees
18 Feb - 19 Feb
The Lofts of North Main Street

Prime Loft of Main Street

9.8 out of 10, Exceptional, (83)
"Location, Layout, View, Decor were great. Could use a deep clean"
The price is SAR 484
SAR 989 total
includes taxes & fees
18 Feb - 19 Feb
Prime Loft of Main Street

Remodeled Kirkwood Guest house

10.0 out of 10, Exceptional, (71)
"A cozy and immaculately kept guest house at a great location. Close to everything. Great hosts ready to answer all your questions. I really enjoyed my stay and will definitely be back."
Remodeled Kirkwood Guest house

Cozy country setting 4 miles from route 66

10.0 out of 10, Exceptional, (4)
"Really nice property! Country setting and nice big living area."
The price is SAR 563
SAR 895 total
includes taxes & fees
18 Feb - 19 Feb
Cozy country setting 4 miles from route 66

‘The Merlot Bungalow’ Defiance Tiny Home on Trail

10.0 out of 10, Exceptional, (3)
"We loved the property and would definitely stay there again. The style of the house is unique, relaxing, and fun, and we give that a 5-star. The accuracy of the description is 4-star because the shower in the bathroom off the kitchen was inoperable. More accurately, it functions as a 2-1/2 bath home. There were also some lightbulbs out and we could not figure out how to operate the living area ceiling lights. Again, we loved the property and would stay there next time we're in the area."
‘The Merlot Bungalow’ Defiance Tiny Home on Trail

New Melle Apartment Near Missouri Wine Country

9.4 out of 10, Exceptional, (3)
"It was clean, homey and yet not too fancy! We felt right at home instantly. Loved the town and it was as described. Only 3 to 4 miles from my Aunts house. We would definately stay there again."
New Melle Apartment Near Missouri Wine Country

Duplex Hideaway in St. Charles, MO

10.0 out of 10, Exceptional, (4)
"The house is cute. Street parking only. Clean but small. The neighborhood was fantastic. In a historical district. Close to many shops, restaurants, and a river side park. Great place to stay with a dog."
The price is SAR 405
SAR 1,023 total
includes taxes & fees
3 Mar - 4 Mar
Duplex Hideaway in St. Charles, MO

1st Capitol Mansion - Suite 401

8.4 out of 10, Very Good, (7)
"The condo is very spacious, with plenty of beds. There are some really cool historic features in the building. Great location. And the host, John, was very helpful."
The price is SAR 296
SAR 840 total
includes taxes & fees
18 Feb - 19 Feb
1st Capitol Mansion - Suite 401

Sunny SparkingClean King bed Apt- CreveCoeurPark

9.6 out of 10, Exceptional, (9)
"Comfortable, clean and close to the venue."
The price is SAR 356
SAR 803 total
includes taxes & fees
18 Feb - 19 Feb
Sunny SparkingClean King bed Apt- CreveCoeurPark

Studio, sleeps 4, patio, short drive to Ski Resort, Six Flags & concert venues

2.0 star property
7.6 out of 10, Good, (5)
"Good location. 3 beds to accommodate our family. "
The price is SAR 281
SAR 544 total
includes taxes & fees
28 Feb - 1 Mar
Studio, sleeps 4, patio, short drive to Ski Resort, Six Flags & concert venues

Private Basement Retreat with a HOT TUB

8.4 out of 10, Very Good, (5)
"Perfect for our needs. People do live upstairs so if you are uncomfortable with that not the place for you!"
The price is SAR 405
SAR 1,073 total
includes taxes & fees
2 Mar - 3 Mar
Private Basement Retreat with a HOT TUB

Main Street Balcony Apartment!

9.4 out of 10, Exceptional, (27)
"Enjoyed staying here"
The price is SAR 506
SAR 1,682 total
includes taxes & fees
2 Mar - 3 Mar
Main Street Balcony Apartment!

Main Street Living! 2 Bedroom Unit right On Main!

10.0 out of 10, Exceptional, (22)
"Apartment was great, very clean , comfortable beds, bathroom was a little on the small side . Awesome location "
The price is SAR 405
SAR 1,325 total
includes taxes & fees
2 Mar - 3 Mar
Main Street Living! 2 Bedroom Unit right On Main!

ENTIRE 2 BRM Apt. ON MAIN STREET...STUNNING VIEWS!!

4.0 star property
10.0 out of 10, Exceptional, (20)
"The property was exactly as described. The location was great (right downtown). We were right across from and next to a bar. It wasn't too loud for us, but it was noticeable. If TV was on, it was fine. There are no TVs in the bedrooms. We had no problem with parking or check-in. Host was always very responsive. Plenty of bath towels but no washcloths and only one hand towel. Would definitely recommend this location if wanting to explore the historic area of St. Charles. "
ENTIRE 2 BRM Apt. ON MAIN STREET...STUNNING VIEWS!!

Amazing Renovated Historic Loft on Main Street

10.0 out of 10, Exceptional, (51)
"Sister trip. Really enjoyed, place is great. I messed up our booking, but the host was super nice about the inconvenience we caused. "
Amazing Renovated Historic Loft on Main Street

Stay on Historic Main!

9.4 out of 10, Exceptional, (23)
"My wife and I stayed for her birthday weekend and had a great time. The property is located at the end of the strip so it was perfect to start the bar hoping. The apartment was very cozy and clean. Definitely recommend for the quick get a way!!"
The price is SAR 405
SAR 942 total
includes taxes & fees
2 Mar - 3 Mar
Stay on Historic Main!

Cozy Studio-Historic Main Street-405 Boones Lick Road

10.0 out of 10, Exceptional, (2)
"This property is just delightful. It was a wonderful stay with such a beautiful backyard and patio. There was a historical marker in the front yard. It was blocks from the historical downtown of St. Charles. It was within walking distance from a Starbucks and shopping in the area. "
Cozy Studio-Historic Main Street-405 Boones Lick Road

Zia New Haven

3.5 star property
9.6 out of 10, Exceptional, (5)
"We absolutely loved our stay. Laura was great!"
Zia New Haven

Wentzville 1 Bedroom Charm

9.6 out of 10, Exceptional, (5)
"This was a nice property in a very convenient location. We really enjoyed our stay. It was not lacking for anything. Would stay here again."
The price is SAR 405
SAR 1,134 total
includes taxes & fees
2 Mar - 3 Mar
Wentzville 1 Bedroom Charm

Western-Themed 2-Bedroom Hideout for Outlaws 204-2

9.0 out of 10, Wonderful, (6)
"Property is very clean, the location is awesome and convenient to historic St. Charles. Plenty of shopping, restaurants and bars within walking distance. The property is perfect for a get away and relax in!!!"
Western-Themed 2-Bedroom Hideout for Outlaws 204-2
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Other property types in Defiance

Spacious*Outdoor Space*Modern*Family*Groups*Modern*Artistic

9.8 out of 10, Exceptional, (37)
"Was in town for a family funeral. House was comfortable and conveniently located. Was very thankful to be able to bring our dog. Will definitely try to stay here again when in town. "
The price is SAR 431
SAR 1,223 total
includes taxes & fees
18 Feb - 19 Feb
Spacious*Outdoor Space*Modern*Family*Groups*Modern*Artistic

Cute spacious Ranch - very safe area - 4 BR 2B- big fenced yard -1800 sft

9.6 out of 10, Exceptional, (14)
"Easy to find, comfortable beds and nice to be able to park the car in the garage."
The price is SAR 525
SAR 1,152 total
includes taxes & fees
26 Feb - 27 Feb
Cute spacious Ranch - very safe area - 4 BR 2B- big fenced yard -1800 sft

The St. Charles Guest House, lovely historic home, fun for families and groups

10.0 out of 10, Exceptional, (123)
"A group of our college friends met for a hockey game/birthday celebration! This home smelt clean the second you walked in the door and was the perfect location! Much thanks for a fabulous weekend! "
The St. Charles Guest House, lovely historic home, fun for families and groups
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What's it like to stay at an apartment in Defiance?
You’ll find 10 apartments to choose from in Defiance for your stay.
Why choose an apartment versus a traditional hotel?
Often more spacious than a traditional hotel room, an apartment includes a kitchen for convenient home-cooked meals. Apartments are ideal for families who want the conveniences of home, and also for couples who want something in a quieter part of town.
What's a favorite apartment for a stay in Defiance?
Here are some of the top apartments in the area: The Lofts of North Main Street: Situated in St. Charles, 19.2 mi/30.8 km from the heart of Defiance. Includes free WiFi, sofa beds, and Smart TVs. Prime Loft of Main Street: Located 19.2 mi/30.9 km away in St. Charles. Free WiFi, sofa beds, and Smart TVs are included. Remodeled Kirkwood Guest house: It’s situated in Kirkwood, 20 mi/32.2 km away. Includes private balconies, sofa beds, and Smart TVs. 1st Capitol Mansion - Suite 401: 18.7 mi/30.1 km away in St. Charles. Cozy country setting 4 miles from route 66: It’s located in Pacific, 14.4 mi/23.1 km from Defiance. Includes Smart TVs.
How many apartments will I be able to find in Defiance?
Expedia has 10 apartments to book in Defiance.
What can I expect from the weather during my trip to Defiance?
Weather is only one factor, but it can really affect your travel plans, especially if you’re planning an extended stay in Defiance. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.
What are the must-see places to visit in Defiance?
Matson Hill Park Trailhead and August A. Busch Memorial Conservation Area are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. While here, Yellow Farmhouse Winery and Chandler Hill Vineyards are other places worth a visit.
What's the best way to get to and around Defiance?
Knowing a bit about the transportation options can save you time when you get to your destination. Fly into St. Louis, MO (SUS-Spirit of St. Louis), which is located 7.5 mi (12 km) from the heart of the city. You can also search for flights into St. Louis Lambert Intl. Airport (STL), which is 23.5 mi (37.8 km) away. If you’d like to explore around the area, you may want a rental car for your journey.